This has been an ongoing debate in hunting circles. However, both firearms are very popular and commonly used for hunting big game.  Research shows more marketing around the 6.5 Creedmoor which can complicate the discussion.  Despite the data, it still boils down to personal preference.

The popularity of the new .308 Winchester cartridge gradually increased as hunters and shooters realized the accuracy and power of the cartridge.  Many of the other short-action cartridges like.260 Remington were descended from the .308 Winchester as well.

See Head to Head Comparisons

While they certainly have different advantages, both cartridges are very accurate, relatively flat shooting, and hit hard enough for use on a variety of game out to several hundred yards.

FAQs

Question – What is the better cartridge for hunting game like mule deer or pronghorn in open country?

Answer – 6.5 Creedmoor

Question – What is the better battle rifle for personal defense?

Answer – .308 Winchester

Question – Which rifle has less recoil?

Answer – 6.5 Creedmoor

Question – Which is the better option for a serious long-range shooter searching for the cartridge best suited for target shooting out to 1,200 yds or so in a precision rifle?

Answer – 6.5 Creedmoor

Question – Do you want a cartridge well suited for elk, moose, caribou, kudu, eland, or red stag hunting?

Answer – .308 Winchester